Originally made , upright in morality and upright in anatomical structure .

Ecclesiastes 7:29 This only have I found: God made mankind upright, but men have gone in search of many schemes."
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Upright in morality and upright in anatomical structure .
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From Adam and Eve , GENESIS 3 http://esv.scripturetext.com/genesis/3.htm who chose to listen to a lie and a deception , man has become morally corrupt and bent over with disease .
ROMANS 5:12 Therefore, just as sin came into the world through one man, and death through sin, and so death spread to all men because all sinned—

There is only one solution to the FALL OF MAN and that is the RISING OF JESUS CHRIST .
ROMANS 5 http://esv.scripturetext.com/romans/5-1.htm
Acts 2:24 But God raised him from the dead, freeing him from the agony of death, because it was impossible for death to keep its hold on him.